PHYSIOLOGY





The History of the Department
The Staff of the Department
Schedule for Lectures 1st Year of Study
Schedule for Lectures 2nd Year of Study
Address


The History of the Department

The Physiology of Timisoara celebrates 50 years, but Pavel Vasici Ungureanu (1806-1881) can be considered its precursor. He was born in Timisoara in 1806 and he finished the first Book of Physiology in 1830, which uses for the first time Romanian anatomical and physiological terminology and was to appear in Buda, under the title: "Anthropology" or "Brief Approacha to Man and his Features".

The history of Physiology begins in the university year 1945-1946, at the time when the head of the Department was Professor Ilie Georgescu (1905-1963), M.D., Ph.D., "Docteur de L`Université de Paris", "Magna cum laudae". Disciple and collaborator of Professor Ion Nisescu (1884-1971), Professor Ilie Georgescu studies the field of hydrogen-ions concentrations, redox potential, acceptors of hydrogen. He determined for the first time the redox potential of hexuronic acids and vitamin C, proving that the latter produces a reversible redox system.

Meantime, the laboratory was organized and apparatus for biochemical tests, reactives, didactic materials were provided. Starting with 1946, the leading of Physiology Department was taken over by a very close collaborator of Daniel Danielopolu (1884-1955), Prof. Marin Popescu, M.D., Ph.D., (1896-1966).

In his formation Prof. Ion Athanasiu (1868-1926), the founder of modern Physiology in our country, had a decisive contribution. Professor Marin Popescu is well-known in the physiological literature for the researches about the origin of extrasistolic pause and for the "Little and ingenious apparatus for direct sanguin transfusion". He invented a lot of medical apparatus and devices, and published 138 scientific papers, his major topics being the nervous and humoral cardiovascular regulation, neurotransmitters and interoceptors physiology, aspects of the portal vein motricity and pharmacodinamy.

Prof. Marin Popescu was member of the Romanian Academy of Science and Medical College, and he was distinguished with: "Commemorative Cross of War" 1916-1918; "The Medal Victory of the Great War" 1916-1918; "The Romanian Crown in degree of knight" 1928, "The Romanian Star in degree of knight" 1939.

In 1949, the Physiological team begun the scientific work, contributing to the study of direct and reflex mechanisms of regulation of the functional systems. two inventions were performed for the scientific research: device for perfusion of isolated mammalians organs, and another one to register the variations of mammalians organs perfusions. in this time, the themes of practical works are enriched, the methods from experimental study on the animals are elaborated.

Between 1963-1964 the Physiological education was conducted by Prof. Ion Cot[escu (1915-1995), disciple of Prof. Rainer, member of Romanian Academy of Medical Science. He modernized the system of Physiological teaching by introducing an extensive chapter: "General Physiology" and Cell Physiology". He also published many appreciated scientific books: the first monograph of electrocardiography in our country, "The living system", "Cell Physiology". In the first decade of physiological education in Timisoara, among the members of the staff were: Ernest Schorscher, Stefan Weiss, Stefania Ducu, Eleonora Zissu, Carabas-Gyulai Monica, Gheorghe Rudas, Ion Rabagia, Ilie Florea, Mihai Tomus, Ioana Crisan.

Between 1964-1983 Prof. Andrei Mirza M.D., Ph.D. (1917-1983) became the leader of the physiological education. He was disciple and collaborator of Prof. Marin Popescu, he worked from 1947 at the Discipline of Physiology and followed the whole hierarchy up to professor and head of Physiology Department. In this time the education together with the research work were improved and the scientific work was centered on clearing the neurohumoral phagocyto-stimulating mechanism, the role of peripheral chemoreception in its activation.

Prof. Francisc Schneider M.D. Ph.D. is the head of the Discipline from 1983 and also head of the Physiology Department from 1992, being the disciple of Prof. Marin Popescu and Prof. Ion Cotaescu. Beginning with 1960 he successively followed the hierarchy degrees and became professor in 1990, full memeber of Romanian Academy of Medical Sciences in 1994 and active member of the European Academy of Sciences and Arts in 1995.

Physiology is studied during three semesters, the lectures being designed to assure the knowledge of Clinical Physiology, taking into account the latest scientific information. The laboratory has been reorganized and the laboratory applications have been assessed in modules. In 1991 the immunophysiological laboratory is set up and endowed with modern devices which allow multiple investigations of cellular and humoral immunology. During the first period, the researches were centered on the exercise and tiredness physiology. In the last years, the airway physiology and immunophysiology are the major research domains. The fields of veins physiology, stress and psycho-neuro-endocrine modulation of immune system were also approached.

The training of didactic staff by scientific and didactic documentation, fellowships and participations to local, national, international scientific meetings has been always assured. The Department of Physiology also offers many opportunities to encourage student participation in scientific activities. At the professional competitions the students from Timisoara acquired the first place by: Lavinia Leanca-Noveanu 1985, Tudor Oprea 1986, Eugen Gornic 1987, Cristina Zegheru 1988.

The discipline organized four National Conferences of Physiology, an International Course of Immunology and Workshop on Flowcytometry. Many years from now on, research contracts in the field of bronchomotricity and immunophysiology, with the Romanian Academy of Medical Sciences, with the Romanian Academy and the Ministry of Education will be developed. The members of the discipline publish "Fiziologia/Physiology", the official journal of the Romanian Society of Physiological Sciences (in english language).

Starting with 1991, three doctoral dissertations were sustained by Tudor Ionel Oprea - "Theoretical and experimental studies on beta-adrenoceptors from the respiratory system", Georgeta Mihalas - "Experimental and clinical researches concerning the implications of calcium and calcium channel blockers in regulation of bronchomotricity" and Vladut Emanoil - "Chronobiological study concerning the tolerance to alternative shift work in glass-blowers". At present, in our discipline other ten thesis are in work. More than 100 graduation papers in physiology have been coordinated.

The methodological guidance concerns the field of Clinical Physiology and Functional Explorations. in this respect, various postuniversity lectures (residency, improvement of medical activity) have been organized. The Laboratory of Clinical Physiology and Functional Explorations in the District Hospital is also directed by the Discipline of Physiology, representing a real model in this field. The teaching staff of the Department also provides research activity within the Laboratory of Applied Physiology of The Medical Research Center.


Sus 
The Staff of the Department

Prof. Doina Drugarin M.D., Ph.D., Clinical Laboratory
Prof. Francisc Schneider M.D., Ph.D., Clinical Physiology
Associated Professor Georgeta Mihalas M.D., Ph.D., Clinical Physiology
Associated Professor Smaranda Gotia M.D., Ph.D., Clinical Laboratory
Associated Professor Rodica Mateescu M.D., Ph.D., Clinical Laboratory
Lecturer Petru Stefaniga Biologist
Lecturer Claudia Mederle M.D., Clinical Physiology
Lecturer Carmen Bunu M.D., Clinical Physiology
Assistent Daniela Cocarla M.D., Clinical Physiology
Assistent Ioana Siska M.D., Clinical Physiology
Assistent Lavinia Noveanu M.D. Clinical Physiology
Asistent Gabriela Tanasie M.D., Clinical Physiology
Assistent Carmen Tatu M.D., Clinical Laboratory
Assistent Daniela Crasnic M.D., Clinical Laboratory
Asistent Ovidiu Coste M.D., General Medicine
Assistent Dan Navolan M.D., General Medicine

Schedule for Lectures 1st year of study - 2nd semester

I. GENERAL PHYSIOLOGY

1. Structure and function. The cell as living unit of the body.
2. Membrane irritability and excitability. Membrane physiology. Transport through the cell membrane.
3. Ionic channels. Membrane transport proteins. G proteins.Membrane receptors.
4.Neuronal physiology. Th resting membrane potential and the action potential.
5.Synapses physiology.
6.Skeletal muscle fiber physiology.
7.The neuromuscular junction.
8.Morphological and functional characteristics of cardiac muscle and smooth muscle.
9.Regulation of body functions. Basic principles of body regulation. Humoral and hormonal control.
10.Nervous control: elementary somatic reflexes and autonomic reflexes.

II. BLOOD PHYSIOLOGY

11. Body fluid compartments. Blood volume. Circulating and stored blood.
12.Blood functions and properties. Blood volume regulation.
13.Water balance and osmotic equilibrium. Regulation of water and ions equilibrium.
14.The acid-base balance.
15.Plasma biohemical composition.
16.Plasma proteins physiology.
17.The red blood cells: structure and chemical composition. Erythropoiesis. Erythrocyte metabolism.
18.The erythrocyte role in oxygen homneostasis. The erythrocyte role in acid-base balance. Iron metabolism.
19.The hemolysis. Spleen physiology. Regulation of erythropoiesis.
20.Leukocytes physiology: granulocytes and monocytes - macrophages.
21.Platelets physiology. Vasoconstrcition and platelet plug formation.
22.Coagulation: blood clotting factors. Intrinsic and extrinsic mechanisms.
23.Fibrinolysis. Coagulation and fibrinolysis regulation.

III. PHYSIOLOGY OF THE GASTRO-INTESTINAL TRACT

24. Secretory functions of the gastro-intestinal tract. Salivary glands secretion. Regulation of salivary glands secretion.
25.Gastric secretion. Regulation of gastric secretion.
26.Pancreatic secretion. Regulation of pancreatic secretion. Bile secretion. Functions of the biliary tree. Bile salts and their role.
27.Intestinal secretion. Regulation of intestinal secretion. Basic principles of gastro-intestinal absorbtion.
28.Digestion and absorbtion of carbohydrates, fats and proteins.
29.The functions of the large intestine. Functional types of movements in the gastro-intestinal tract.
30.Mastication (chewing). Deglution (swallowing). Gastro-intestinal motor functions. Defecation

Schedule for Lectures 2nd year of study 1998-1999

I. CARDIOVASCULAR PHYSIOLOGY

1.Organization of cardiovascular system. Morphological and functional characteristics of heart: cardiac muscle physiology. Contraction"s mechanism in cardiac muscle. Specialized excitatory and conductive system of th heart. The cardiac resting and action potential.
2.Sinus node physiology. Atrioventricular node physiology. Pacemaker activity (automatism) of the heart. Principal physiological properties of cardiac muscle: excitability and conductivity.
3.Mechanical properties of myocardium. Relation of tension to lenght in cardiac muscle (Frank-Starling mechanism). Relation force-velocity. Myocardial contractility (inotropism). The preload and afterload physiology.
4.The cardiac cycle. The pressure values in the heart cavities during the cardiac cycle (manometric cardiogram). Function of the valves. Heart sounds (phonocardiogram).
5.Cardiac output. Cardiac work. Myocardial metabolism.
6.Coronary circulation.
7.Physical characteristics of the circulation. Interrelationships among pressure, flow, velocity and cross-sectional areas. Blood viscosity. Resistance to blood flow. Vascular distensibility and compliance.
8.Morpho-functional characteristics of vascular smooth muscle. Arterial circulation physiology.
9.The microcirculation physiology. The capillary exchange physiology. Autoregulation of microcirculation. Circulation in veins. Lymphatic system.
10.Cerebral circulation. Skeletal muscle circulation. Cutaneous circulation. Fetal circulation.
11.Cardiovascular control: autoregulation of the heart. Sympathetic and parasympathetic innervation. Vasomotor centres that control cardiac actvity. Reflex control of cardiac activity.
12.Control of arterial pressure: neural and endocrine regulation. Control of cardiovascular activity during exercise.

II. RESPIRATORY PHYSIOLOGY
13.Functional organization of the pulmonary respiration. Function of the respiratory passage ways.
14.Pulmonary ventilation physiology: pulmonary volumes and capacities.
15.Pulmonary perfusion physiology. Physics of gas diffusion through the respiratory membrane.
16.Transport of oxygen and carbon doxide in the blood. Celular respiration.
17.Regulation of respiration: control of overall respiratory center activity. The neural-reflex regulation of respiration.
18.Neuro-humoral regulation of respiration. Chemical control of respiration. The newborn respiration: the first respiration physiology. Regulation of respiration during exercise. Regulation of airways tone.

III. RENAL PHYSIOLOGY

19. Functional organization of the kidney and urinary tract.
20.Tubular function: reabsorbtion and secretion of different substances.
21.Renal excretion of blood components.
22.Renal control of acid-base balance.
23.Regulation of renal function. Autoregulation of renal activity. Neuro-endocrine regulation of renal activity.
24.Urinary tract physiology. Micturition.

IV. ENDOCRINE PHYSIOLOGY

25.Endocrine glands physiology. Endocrine functions of diencephalon. The pineal gland.
26.Endocrine hypothalamus. The pituitary gland physiology.
27.The thyroid gland. Endocrine functions of the pancreas.
28.The adrenal cortex and adrenal medulla.
29.Calcium and phosphate homeostasis. Tissue hormones.
30.The gonads: development aand function of the reproductive system.

V. METABOLISM. NUTRITION. TEMPERATURE REGULATION
31.Metabolism of carbohydrates. Blood glucose regulation.
32.Protein physiology. Lipid metabolism. Adipose tissue.
33.Liver physiology.
34.Dietary balance. Regulation of food intake.
35.Temperature regulation.

VI. THE NERVOUS SYSTEM: GENERAL PRINCIPLES AND SENSORY PHYSIOLOGY
36.Organization of the nervous system. Basic functions of synapses. Interpolated neurons.
37.Spinal cord physiology.
38.The medulla oblongata, pons and midbrain physiology.
39.The cerebellum and diencephalon physiology.
40.The reticular formation. The basal ganglia and extrapyramidal system.
41.The limbic system. The autonomic nervous system physiology.
42.The cerebral cortex physiology.
43.Cortical control of motor function: posture and movement.
44.The sense organs. Visceral sensation. Visual function.
45.Audition. Vestibular sensation and maintenance of equilibrium. Olfactory and gustatory sensations.

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