Contact us

Address: Eftimie Murgu Square, No. 2, cod 300041, Timişoara
Phone: 0256/204476
E-mail: savoiugema@umft.com, alexandra.petrus@umft.ro

Academic staff

Head of Discipline

📲 Phone: +40256/494604

📧 Email: savoiugema@umft.ro

📃 Curriculum vitae

Members

📲 Phone: +40256/494604

📧 Email: alexandra.petrus@umft.ro

📃 Curriculum vitae

General presentation

The discipline of Anatomy, Physiology and Pathophysiology is a fundamental discipline that appeared with the establishment of the faculty, in 1991, under the leadership of Prof. Alexandru Cristescu, PhD (member of the Academy of Medical Sciences and trainer of the Timisoara School of Pathophysiology). In 1998, the study program in French of the Pharmacy specialization was established, which still operates at the Faculty of Pharmacy in Timişoara. From 2001 to 2004, the head of discipline was Prof. Anca Dragomirescu, PhD. In 2009 the head of the discipline becomes Assoc. Prof. Săvoiu Balint Germaine, PhD.

Anatomy, Physiology and Pathophysiology is taught to the first- and second-year students of the Faculty of Pharmacy (Romanian and French sections), as well as to first-year students from the Specialization of Pharmacy Assistance – Lugoj and Medical Cosmetics and Cosmetic Technology.

The analytical program is complete and modern, in accordance with the programs of similar disciplines from other Pharmacy faculties in the country, but also in Europe. Both in the courses and the practical activities, the teaching activity is a modern one, focused on the student, in which the interactive aspect of the communication with the students is stimulated. The course provides theoretical support that allows the understanding and accumulation of basic anatomical, physiological and pathophysiological knowledge of the human body, necessary to understand the strategy of diagnosis and treatment, as well as the mechanisms of action of drugs in the human body. In the practical works students will deepen the notions of anatomy, physiology and pathophysiology (presented in the course) and will correlate these notions with the (para)clinical changes the diseases induce (detailed and exemplified by case studies, analysis and interpretation of analysis bulletins). The practical works are carried out in a room equipped with computers, programs and equipment that allow the study of the human body and functional disorders corresponding to various pathologies (imaging study, anatomy, physiology and virtual pathophysiology, other direct methods).

Through the analytical program, students will develop and consolidate a theoretical knowledge base regarding human anatomy, the functionality of structures in the human body, the mechanisms that lead to pathological processes, their manifestations and diagnosis, notions that are necessary to facilitate the understanding of administration routes, mechanisms of action and the metabolism of drugs in the body, and also for his activity as a future pharmacist.

Scientific research projects
  • Strategii cardioprotectoare la reperfuzie-mitocondria ca multipla ţintă terapeutică, Parteneriate tip PC, nr.contract 42122/2008, 2008 – 2011, 138300 2009, Membru : Germaine Săvoiu-Balint
  • Tehnologii inovative de producere a unor alimente funcţionale de origine vegetală cu impact asupra sănătăţii umane, PC,  contract 610008/18 .09. 2007,Coordonator de proiect: Universitatea Babeş-Bolyai – Cluj-Napoca, 2009, Membru : Germaine Săvoiu-Balint
  • A pan- European research network for Complementary and Alternative Medicine, nr. contract 241951, Fp7-Health-2009-3.1-3, 2009, Simona Drăgan Responsabil proiect, Membru : Germaine Săvoiu-Balint.
  • Grantul de cercetare CNCSIS tip A: „Beneficiul recuperarii cardiace comprehensive a pacientilor cu by-pass aorto – coronarian asupra disfunctiei endoteliale – studiu corelativ cu polimorfismul NO sintetazei endoteliale”. Membru : Germaine Săvoiu-Balint
  • Programul Parteneriate în cercetarea fundamentalǎ inovativǎ UMFT, III-C1-PCFI-2014/2015, Proiect SYNTANTITUM, „Sinteza unor compuşi cu potenţială activitate antitumorală prin reacţii de derivatizare şi caracterizarea acestora prin tehnici hifenate. Evaluarea activităţii antiangiogenice, antineoplazice şi antiinflamatoare”, 30000 euro, 2014-2015 Director de proiect, conf. univ. dr. Fuliaş Adriana-Violeta, Membru : Germaine Săvoiu-Balint
  • Programul Parteneriate în cercetarea fundamentală inovativă a UMFVBT, Grant UMFVBT PIII-C5-PCFI-2017/2018: ”Rolul vitaminei D în modularea funcției vasculare și mitocondriale la nivelul țesutului adipos pe model animal și la om” – acronim VASC-ADIPO-MIT, 2017-2018, Membru : Germaine Săvoiu-Balint, Mioc (Petruș) Alexandra
  • Proiect pentru tineri cercetători (PII-C4-TC-2016): ”Screening-ul rezervei funcționale bioenergetice în sângele periferic la pacienții cu hemopatii maligne” câștigat prin competiţia internă a UMF “VICTOR BABEŞ” Timişoara, 2016, Director proiect: Mioc (Petruș) Alexandra
  • Proiect de cooperare transfrontalieră Ungaria-România 2007-2013 ”Twinning Project for the Development of the Research Infrastructure – HURO-TWIN” cod 1101/082/2.2.1, 2013-2015, Membru: Mioc (Petruș) Alexandra
  • Projects of Exploratory Research l (IDEI): ”Evaluation of cardioprotective effects of K-ATP channels modulation ” code PCE-2012-4-0512, 2013-2016, 2016 Membru: Mioc (Petruș) Alexandra
  • Programul Parteneriate în cercetarea fundamentală inovativă a UMFVBT, Grant UMFVBT PIII-C2-PCFI-2015/2016, “Noi abordări farmaceutice pentru modularea biodisponibilităţii unor flavonoide cu potenţial chemopreventiv pentru melanomul malign” – acronim FLAVOFORM. Membru: Mioc (Petruș) Alexandra
  • Romania-France Cooperation Mobilities Programme „Brancusi-Hubert Curien”, “Novel Insights in Vascular Protection Mediated By Purinergic Signaling” – PUR-VASC-PROTECT , project no. 75 BM, 2017-2018, Membru: Mioc (Petruș) Alexandra
Reprezentative scientific publications
  • Savoiu-Balint G, Iovanescu G, Stanca H, Popoiu Calin, Boia E, Popovici Ramona, Bolintineanu S.L. The protective effect of HDL-cholesterol in patients with essential hypertension. Revista de Chimie. 2017; 68:949-952.
  • Savoiu-Balint G, Boruga O,Popovici R, Bolintineanu L, Mihaescu R, Popoiu C, Boia E, Petrus A, Andoni M. The Effects of Hg 2+ on Endothelial Function in Electronic Cigarette Smokers with Coronary Artery Disease. Revista de Chimie. 2017; 68(4):711-714.
  • Savoiu-Balint G, Andoni M, Popovici R, Rusu L, Citu I, Rumel R, Cioban V. The Effect on Health of Some Cardiovascular Risk Factors. Rev Chim. 2017; 68(10):2237-2242.
  • Germaine Savoiu-Balint, Alexandra Petrus, Rodica Mihaescu, Daniela Ionescu, Cosmin Citu, Iosif Marincu, Claudia – Crina Toma. Role of atorvastatin ((3r,5r)-7-<2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl>-3,5-dihydroxyheptanoic acid) on endothelial function in patients with dyslipidemia. Chim.(Bucharest), 2015, 66(10): 833-836.
  • Ovidiu Boruga, Germaine Savoiu, Elena Hogea, Alina Heghes, Elena Voichita Lazureanu. Correlation between high- sensitivity C-reactive protein and intima media thickness in patients with coronary artery diseases and essential hypertension. Rev.Chim.(Bucharest), 2015, 66(10): 746-749.
  • Germaine Savoiu Balint, Gheorghe Iovanescu, Calin Popoiu,marian Jenel Patrascu,Claudia Borza,Georgeta Coneac, Ionut Ledeti, Adriana Fulias, Marius Butur, Vicentiu Vlaia, Ramona Amina Popovici Evaluation of the Association of Hyperuricaemia With The Dysfunction Of Endothelium.. Exp Clin Cardiol. 2014; 20(1):1269-1276.
  • O Boruga, G Savoiu, E Hogea, A Heghes, EV Lazureanu. Correlation Between High-sensitivity C-reactive Protein and Intima Media Thickness in Patients with Coronary Artery Diseases and Essential Hypertension. Rev Chim. 2015; 66(10):1651-1654.
  • Alexandra Petrus, Corina Ratiu, Lavinia Noveanu, Rodica Lighezan, Mariana Rosca, Danina Muntean, Oana Duicu. Assessment of Mitochondrial Respiration in Human Platelets. Rev. Chim. (Bucharest). 2017; 68(4):768-771.
  • Mioc, Alexandra; Mioc, Marius; Ghiulai, Roxana; Voicu, Mirela; Babuta, Roxana; Trandafirescu, Cristina; Dehelean, Cristina; Coricovac, Dorina; Soica, Codruta Marinela. Gold nanoparticles as targeted delivery systems and theranostic agents in cancer therapy. Current medicinal chemistry. 2019; 26(35): 6493-6513. DOI: 10.2174/0929867326666190506123721
  • Alexandra Petruș, Oana M. Duicu, Adrian Sturza, Lavinia Noveanu, Loránd Kiss, Maria Dănilă, István Baczkó, Danina M. Muntean, Norbert Jost. Modulation of Mitochondrial Respiratory Function and ROS Production by Novel Benzopyran Analogues. Can J Phys Pharmacol. 2015; 93(9): 811-8
  • Codruta Soica, Mirela Voicu, Roxana M. Ghiulai, Cristina Dehelean, Roxana Racoviceanu, Cristina Trandafirescu, Oana Rosca, Gabriela Nistor, Mioc Marius, Alexandra Mioc. Natural compounds in sex hormone-dependent cancers: the role of triterpenes as therapeutic agents. Frontiers in Endocrinology. 2021; 11: 612396. DOI: 10.3389/fendo.2020.612396.
  • Petrus AT, Lighezan DL, Danila MD, Duicu OM, Sturza A, Muntean DM, Ionita I. Assessment of platelet respiration as emerging biomarker of disease. Physiol Res. 2019; 68(3):347-363. DOI: 10.33549/physiolres.934032.
  • Macasoi, I; Pavel, IZ; Moaca, AE; Avram, S; David, VL; Coricovac, D; Mioc, A#; Spandidos, DA; Tsatsakis, A; Soica, C; Dumitrascu, V; Dehelean, C. (# corresponding author). Mechanistic investigations of antitumor activity of a Rhodamine B-oleanolic acid derivative bioconjugate. Oncology Reports. 2020; 44(3): 1169-1183. DOI: 10.3892/or.2021.7981
  • Dorina Coricovac, Cristina Adriana Dehelean, Iulia Pinzaru, Alexandra Mioc* (*corresponding author), Oana-Maria Aburel, Ioana Macasoi, George Andrei Draghici, Crina Petean, Codruta Soica, Madalina Boruga, Brigitha Vlaicu, Mirela Danina Muntean. Assessment of Betulinic Acid Cytotoxicity and Mitochondrial Metabolism Impairment in a Human Melanoma Cell Line. Int J Mol Sci. 2021; 22, 4870. https://doi.org/10.3390/ijms2209487
Publications (books) for students

Courses:

  • Savoiu Germaine, Borza C., Serban C., Petrus Alexandra.Anatomia, fiziologia si fiziopatologia sistemelor: cardiovascular, endocrin, osos, muscular, digestiv, renal”. Editura Eurobit, Timisoara, 2014.
  • Germaine Savoiu, Claudia Borza, Corina Serban,Fiziologia si fiziopatologia  metabolismelor “, Ed. Eurobit, 130 pagini,  2013, ISBN: 0789731320137.
  • Germaine Savoiu, Carmen Cristescu, Corina Serban, Anatomia, Fiziologia si Fiziopatologia Sistemelor, Eurobit, 141 pagini, 2010, ISBN:9789736207136
  • Mioc Alexandra, Germaine Savoiu. Anatomie, Fiziologie și Fiziopatologie. Note de curs pentru asistenții de farmacie. Victor Babeș, Timișoara, 2014.

Courses for master students:

  • Claudia Borza, Germaine Savoiu, Carmen Cristescu, Fiziologia si fiziopatologia imbatranirii, EdEurobit,109 pagini,, 2010, ISBN9789736207143

Practical activities:

  • Germaine Savoiu-Balint, Carmen Cristescu, Corina Serban, “Anatomie,Fiziologie, Fiziopatologie“, Aplicatii practice, Ed. Eurobit, 148 pagini, 2011, ISBN:9789736208157.
  • Alexandru Cristescu, Danina Muntean, Ovidiu Fira-Mladinescu, Ioana Mozos, Germaine Savoiu, Corina Gorun, D. Barglazan, Nicoleta Mirica, Oana Duicu, Camelia Costea, Andreea Raducan.  Lucrari practice. Editura Fleming, 170 de pagini, 2005, ISBN: 973-98153-8-3.
  • Germaine Savoiu, Carmen Cristescu, Oana Duicu, “Anatomie, Physiologie, PhysiopathologieAplications, Ed. Eurobit. 168 pagini, 2010, ISBN 9789736206290
Recomended bibliography for students:
  • Ganong W.F, McPhee S.J. Pathophysiology of Disease An Introduction to Clinical Medicine,, 5th Ed., Lange Medical Books/McGraw-Hill, 2006
  • Alexandru Cristescu Fiziopatologia Sistemelor.Editura Fleming,301 de pagini,2003,ISBN 973-98153-6-7
  • Alexandru Cristescu, Fiziopatologia sistemelor digestiv, renal, aparare nespecifica, metbolisme, Editura Fleming, 302 pagini, 2003, ISBN 973-98153-7-5
  • Borza C., Savoiu G., Cristescu C. Fiziologia si Fiziopatologia Imbatranirii. Ed. Eurobit. Timisoara 2012.
  • Noveanu L., Fira-Mladinescu O., Savoiu G. Functiile Endoteliului Arterial. Implicatii Fiziologice si Patologice. Ed. Eurobit. Timisoara 2006.
  • Guyton A.C, Hall J.E. Textbook of Medical Physiology, 11th Ed., Elsevier Inc., 2006
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