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Address: 2, Eftimie Murgu Sq., Timisoara, 3000411
Phone: 0256494604
E-mail: cadehelean@umft.ro

Academic staff

Head of Discipline

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📧 Email: cadehelean@umft.ro

📃 Curriculum vitae

         

Membri

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General presentation

The discipline of Toxicology is part of the Specialized Pharmaceutical Sciences and was founded and introduced in the analytical program of the Faculty of Pharmacy since Faculty’s foundation in 1991. Toxicology has been described as an autonomous science since 1815, by the founder of modern toxicology, Mathieu Joseph Bonaventura Orfila, and since then has known a significant progress, the initial descriptive science became an applied science.

Toxicology is considered a translational science, where the principles of chemistry, biochemistry, pathology, physiology, immunology, ecology, biomathematics, and statistics are combined with clinical ones to determine and to solve / reduce the risks for human health.

The main directions of activity in toxicology consist in:

  • the study of toxics, which can be found normally or accidentally in the body, in terms of origin, physical, chemical, and biological properties, mechanisms of action, isolation, identification, and dosage methods, and measures to combat their harmful actions
  • the analysis of the adverse effects determined by a toxic substance concerning their occurrence, nature, incidence, mechanism of action and risk factors
  • the analysis of the adverse effects observed at the administration of medicinal compounds within therapeutic limits (pharmacotoxicology) that confines the exceeding of the therapeutic barrier towards the toxic area
  • identification of toxicants’ mechanisms of action by applying different techniques (e.g., molecular biology techniques), for the knowledge and understanding of the processes involved in carcinogenesis or metabolism of xenobiotics.

Brief history of the discipline

Since 2004, the Discipline of Toxicology is coordinated by Professor  Cristina Adriana Dehelean, who was constantly concerned with increasing the quality of teaching, but also with increasing the national and international scientific visibility. From this perspective, postgraduate courses, scientific circles, summer schools and workshops for students and specialists in the field are organized annually, with the participation of distinguished guests from the country and abroad. In order to increase the quality of the research activity, high-performance equipment was purchased, which led to new opportunities and research directions for students, master and doctoral students of the discipline. They can conduct their research activities within the Center of Advanced Research – FARMTOX coordinated by Prof. Cristina Dehelean.

The role of discipline in the professional training of pharmacists

The main teaching objectives are represented by the study of toxicity induced by industrial toxics, classes of medicinal drugs, drugs, pesticides, mycotoxins, food additives, detergents, toxic substances, radiation, and the understanding of the general principles of toxicology. At the end of the 5 years of academic courses, the future specialist in the field of pharmacy must have a broader view regarding the multiple toxicological risks that a person can be exposed daily and a practical orientation in the relationship with the patients.

The Discipline of Toxicology and Drug Industry offers a rich curriculum in the field of undergraduate, master, doctoral and residency programs.

The educational offer includes the following compulsory courses and practical works within the academic program for pharmacists:

  • Medical-pharmaceutical terminology – I Pharmacy, Romanian and French series
  • First aid and medical emergencies – I Pharmacy, Romanian and French series
  • Semiology – pharmaceutical applications – II Pharmacy, Romanian and French series
  • Pharmacogenetics – II Pharmacy, Romanian and French series
  • Public health – II Pharmacy, Romanian and French series
  • Biological medicines – III Pharmacy, Romanian and French series
  • Toxicology – IV Pharmacy, Romanian and French series
  • Methodology of scientific research – IV Pharmacy, Romanian and French series
  • Homeopathic medicines and veterinary medicines – IV Pharmacy, Romanian and French series
  • Drug industry and pharmaceutical biotechnologies – V Pharmacy, Romanian and French series
  • Toxicology – V Pharmacy, Romanian and French series
  • Pharmacovigilance – V Pharmacy, Romanian and French series

For short-term undergraduate studies (Pharmaceutical Assistance – ASF-L, Medical Cosmetics – CM) the educational offer includes the following compulsory courses and practical works:

  • Pharmaceutical and medical terminology – I ASF-L
  • First aid measures – I ASF-L
  • Elements of toxicology – II ASF-L
  • Bioethics and pharmaceutical deontology – II ASF-L
  • Methodology of scientific research – II ASF-L
  • Elements of toxicology – III ASF-L
  • Elements of industrial pharmaceutical technology – III ASF-L
  • Elements of pharmaceutical management and marketing – III ASF
  • Pharmaceutical legislation – III ASF-L
  • Notions of pharmacovigilance – III ASF-L
  • Hygiene-prophylaxis and notions of epidemiology – I CM
  • Histology and histopathology of the skin – I CM
  • First aid measures and medical emergencies – I CM

It should also be noted that, within the educational offer of our discipline, there are also included the following optional courses, which have the role of completing and improving the informational and practical baggage of the future specialist:

  • Toxic plants – III Pharmacy, Romanian and French series; and III ASF-L
  • Nutrition and dietary products – III Pharmacy, Romanian and French series
  • Pharmaceutical entrepreneurship – III Pharmacy, Romanian and French series; and III ASF-L
  • Analytical evaluation of biomarkers – IV Pharmacy, Romanian and French series
  • Toxicomania/Drug addiction – V Pharmacy, Romanian and French series
  • OTC supplements – V Pharmacy, Romanian and French series
  • Pharmacogenomics – II ASF-L
  • Biological drugs – II ASF-L
  • Homeopathic products and veterinary products – III ASF-L

All optional courses have the role of expanding the area of ​​theoretical knowledge and improving the individual professional perspective with new elements on possible pathologies secondary to the use of various types of drugs, chemicals, drugs, plants, as well as alternative remedies to situations that can be encountered in the daily practice of the future pharmacist.

The coordinator of the discipline, Prof. Cristina Dehelean coordinates undergraduate bachelor’s degree, dissertation, and doctoral dissertations. The members of the discipline coordinate a minimum number of 30 dissertations (licenses, dissertation) annually.

Starting with the academic year 2017/2018, Prof. Cristina Adriana Dehelean is the coordinator of the volunteer program for students “Volunteering in the activity of academic development” (VADA) within the discipline, together with Assoc. Prof. Iulia Pînzaru and Assoc. Prof. Dorina Coricovac. Within the program, 2 students were active in the academic year 2017/2018; 3 students in 2018/2019; 5 students in 2019/2020, 4 students in 2020/2021 and 4 students in 2021/2022.

Books written by the members of the discipline

  1. A. Dehelean, D. Gheorgheosu, D. Ionescu. Noţiuni de toxicologie general. Editura „Victor Babeş” Timişoara, 2013, ISBN 978-606-8456-14-0
  2. A. Dehelean, C. Danciu, G.M. Simu, C.M. Şoica. Elemente de metodologia cercetării ştiinţifice. Editura „Victor Babeş” Timişoara, 2013, ISBN 978-606-8456-13-3
  3. E. Coricovac, F.M. Andrica, S.A. Ciurlea, I. Pînzaru. Elemente de toxicologie industrială şi a mediului. Editura „Victor Babeş” Timişoara, 2014, ISBN 978-606-8456-30-0
  4. Coricovac, C. Dehelean, I. Pînzaru, A. Moacă, Noi aspecte în ceea ce privește utilizarea plantelor toxice, Editura “Victor Babeș” 2018, ISBN 978-606-786-107-5

Master’s degree studies

Starting with 2015, Prof. Cristina Dehelean is the coordinator of the 2-year master’s program entitled: “OTC drugs, food supplements, cosmetics.” The disciplines included in the master’s program offer the students skills and abilities in the field of OTC pharmaceuticals, food supplements and cosmetics; they acquire up-to-date information in order to provide advice and expertise in the field of over-the-counter medicines, the possibility to explain and argue medical recommendations, advise on herbal preparations, advise clients on cosmetics, prosthetics and para pharmaceuticals products, and provide advice on the safety of OTC medicines, herbal preparations and cosmetics.

The discipline of Toxicology and Drug Industry ensures within the master’s program “Formulation and evaluation of the dermato-cosmetic product” the course and practical works of the Cosmetovigilance and safety of the dermato-cosmetic product and the optional course Management of research projects.

Prof. Cristina Dehelean coordinates courses and internships with residents of Clinical Pharmacy specialty.

Student scientific events

The coordinator of the discipline, Prof. Cristina Adriana Dehelean, together with the members of the discipline, have organized over time various scientific student events:

  • Summer School Dermo-cosmetic products based on medicinal plants, 17-19 Iulie 2019 Timișoara
  • 1st International Summer School of Medicinal Plant Pharmaco-Toxicology, 2-13 Iulie 2018 Timișoara, România
  • WORKSHOP – Dermo-cosmetic products as formulations. safety testing of cosmetic products, 13-14 Iunie, 2019, Timișoara, România
  • WORKSHOP – Plantele medicinale în prezent – incidență, compoziție și utilizare (Medicinal Plants at present – incidence, composition and use), 16-17 Octombrie, 2018, Timișoara, România
  • WORKSHOP – Siguranța produselor pe bază de plante medicinale (Safety of medicinal plants products), 22-23 November, 2018, Timișoara, România

Professor Cristina Adriana Dehelean is also the coordinator of the online platform FITOSCIENCE – www.umft.ro

Scientific activity / Representative publications

Currently, the discipline has research laboratories, which are part of the Research Center for Pharmaco-toxicological Evaluations (FARMTOX), coordinated by Prof. Cristina Dehelean. The laboratories of FARMTOX are equipped for: (1) obtaining plant extracts, isolating biologically active compounds, derivatizing them and / or obtaining micro and nano formulations with extracts and active biological compounds of interest, their physicochemical characterization; (2) in vitro studies on cell cultures (healthy cells and tumoral) 2D but also on reconstructed human tissue (3D) and (3) studies in ovo (on embryonated egg) and in vivo non-invasive (2nd Floor, Old Building of Faculty of Pharmacy).

The scientific activity carried out within the Research Center for Pharmaco-toxicological Evaluations (FARMTOX) by the members of the discipline, is a rich one, consisting of over 200 ISI papers published, visible on the Web of Science and participation in national scientific events and international.

Representative publications:

  1. Dehelean, CA; Lazureanu, V; Coricovac, D; Mioc, M; Oancea, R; Marcovici, I; Pinzaru, I; Soica, C; Tsatsakis, AM; Cretu, O. SARS-CoV-2: Repurposed Drugs and Novel Therapeutic Approaches-Insights into Chemical Structure-Biological Activity and Toxicological Screening, Journal of Clinical Medicine, 2020, 9, 2084; doi:10.3390/jcm9072084. IF 4.241
  1. Dehelean CA, Marcovici I, Soica C, Mioc M, Coricovac D, Iurciuc S, Cretu OM, Pinzaru I. Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy. Molecules. 2021, 26(4), 1109. doi: 10.3390/molecules26041109. IF = 4.411
  1. Coricovac D, Dehelean CA, Pinzaru I, Mioc A, Aburel OM, Macasoi I, Draghici GA, Petean C, Soica C, Boruga M, Vlaicu B, Muntean MD. Assessment of Betulinic Acid Cytotoxicity and Mitochondrial Metabolism Impairment in a Human Melanoma Cell Line. Int J Mol Sci. 2021, 22(9), 4870. doi: 10.3390/ijms22094870 IF 5.923
  2. Pinzaru I, Chioibas R, Marcovici I, Coricovac D, Susan R, Predut D, Georgescu D, Dehelean C. Rutin Exerts Cytotoxic and Senescence-Inducing Properties in Human Melanoma Cells. Toxics. 2021, 11(1), 152. IF 4.146
  3. Blidisel A, Marcovici I, Coricovac D, Hut F, Dehelean CA, Cretu OM. Experimental Models of Hepatocellular Carcinoma—A Preclinical Perspective. Cancers. 2021, 13(15), 3651. doi:10.3390/cancers13153651 IF 6.639
  1. Pinzaru I, Tanase A, Enatescu V, Coricovac D, Bociort F, Marcovici I, Watz C, Vlaia L, Soica C, Dehelean C. Proniosomal Gel for Topical Delivery of Rutin: Preparation, Physicochemical Characterization and In Vitro Toxicological Profile Using 3D Reconstructed Human Epidermis Tissue and 2D Cells. Antioxidants (Basel). 2021, 10(1), 85. doi: 10.3390/antiox10010085. IF 6.312
  2. Pinzaru I, Sarau C, Coricovac D, Marcovici I, Utescu C, Tofan S, Popovici RA, Manea HC, Pavel IE, Soica C, Dehelean C. Silver Nanocolloids Loaded with Betulinic Acid with Enhanced Antitumor Potential: Physicochemical Characterization and In Vitro Evaluation. Nanomaterials (Basel). 2021, 11(1), 152. doi: 10.3390/nano11010152. IF 5.076
  3. Moacă EA, Watz CG, Socoliuc V, Racoviceanu R, Păcurariu C, Ianoș R, Cîntă-Pînzaru S, Tudoran LB, Nekvapil F, Iurciuc S, Șoica C, Dehelean CA. Biocompatible Magnetic Colloidal Suspension Used as a Tool for Localized Hyperthermia in Human Breast Adenocarcinoma Cells: Physicochemical Analysis and Complex In Vitro Biological Profile. Nanomaterials (Basel). 2021, 11(5), 1189. doi: 10.3390/nano11051189. IF 5.076
  4. Macașoi I, Pavel IZ, Moacă AE, Avram Ș, David VL, Coricovac D, Mioc A, Spandidos DA, Tsatsakis A, Șoica C, Dumitrașcu V, Dehelean C. Mechanistic investigations of antitumor activity of a Rhodamine B-oleanolic acid derivative bioconjugate. Oncol Rep. 2020, 44(3), 1169-1183. doi: 10.3892/or.2020.7666. IF 3.906
  5. Farcas CG, Dehelean C, Pinzaru IA, Mioc M, Socoliuc V, Moaca EA, Avram S, Ghiulai R, Coricovac D, Pavel I, Alla PK, Cretu OM, Soica C, Loghin F. Thermosensitive Betulinic Acid-Loaded Magnetoliposomes: A Promising Antitumor Potential for Highly Aggressive Human Breast Adenocarcinoma Cells Under Hyperthermic Conditions. Int J Nanomedicine. 2020, 15, 8175-8200. doi: 10.2147/IJN.S269630. IF 6.4
  6. Draghici, GA; Dehelean, C; Pinzaru, I; Bordean, DM; Borozan, A; Tsatsakis, AM; Kovatsi, L; Nica, D. Soil copper uptake by land snails: A semi-field experiment with juvenile Cantareus aspersus snails. Environmental Toxicology and Pharmacology, 2019, 72: UNSP 103243, DOI: 10.1016/j.etap.2019.103243 IF = 3.292
  7. Sipos S, Moacă E-A, Pavel IZ, Avram Ș, Crețu OM, Coricovac D, Racoviceanu R-M, Ghiulai R, Pană RD, Șoica CM, Borcan F, Dehelean CA, Crăiniceanu Z. Melissa officinalis L. Aqueous Extract Exerts Antioxidant and Antiangiogenic Effects and Improves Physiological Skin Para Molecules. 2021, 26(8), 2369. https://doi.org/10.3390/molecules26082369 IF 4.411

Research Projects

The research activity carried out by the members of the discipline is notable, materialized in several research projects, financed from national and international funds. Among the funded and ongoing research projects, we list:

  1. CNFIS-FDI-2021-0498 Title: Dezvoltarea bazei de practică în domeniul plantelor medicinale a UMF Victor Babeș Timișoara / Development of the practice base in the field of medicinal plants of the “Victor Babes” University of Medicine and Pharmacy Timisoara; Manager: Prof. Cristina Dehelean; May 2021 – December 2021
  2. PN-III-P1-1.1-TE-2019-2134, (BAPRONIO) Title: Redarea către piața dermocosmetica a unei formulari topice moderne cu acid betulinic încorporat in proniozomi / Delivery to the dermocosmetic market of a modern topical formulation with betulinic acid encapsulated in proniosomes; Manager: Assoc. Prof. Dorina Coricovac; 2020 – 2022
  3. PhD Internal Project – 4DOC/1276/30.01.2020, (TRITERPENS@MNP), Title: Nanoparticule magnetice ca suport pentru principii active antitumorale de tip triterpenic / Magnetic nanoparticles as support for triterpenic antitumor active principles; Manager: Lect. Elena Alina Moacă; 2020 – 2022
  4. PN-III-P1-1.1- PD-2019-1231, Title: Noi perspective privind chemoprevenția cancerului cutanat: evaluarea acidului maslinic și al unui derivat de acid maslinic încorporați în nanoemulsii / New perspectives on skin cancer chemoprevention: evaluation of maslinic acid and a maslinic acid derivative incorporated in nanoemulsions; Mentor: Prof. Cristina Adriana Dehelean; 2020-2023
  5. ERASMUS project 2019-1-RO01-KA203-063499, Title: Cooperation on innovation and exchange of good practice in the hypoglycemia diet for people with diabetes, Manager project partner: Prof. Cristina Adriana Dehelean; 2019 – 2021
  6. CNFIS-FDI-2019-0393, Title: Centru de dezvoltare profesională în domeniul produselor dermato-cosmetice pe bază de plante medicinale / Center for professional development in the field of dermato-cosmetic products based on medicinal plants; Manager: Prof. Cristina Adriana Dehelean; May 2019 – December 2019
  7. CNFIS – FDI – 2018 – 0159, Title: Centru de dezvoltare a abilităților practice în domeniul plantelor medicinale / Center for the development of practical skills in the field of medicinal plants; Manager: Prof. Cristina Adriana Dehelean; May 2018 – December 2018
  8. PN-III-P1-1.1-PD-2016-1982, Title: Noi perspective privind mecanismul de acțiune al acidului betulinic ca agent antimelanom / New insights into the antimelanoma mechanism of action of betulinic acid; Manager: Assoc. Prof. Dorina Coricovac; Mentor: Prof. Cristina Adriana Dehelean; 2017-2019
  9. Axa 1 a POC – ANCS/ POC-A1- A1.1.4 – E-2015 (NUTRIGEN), Title: Utilizarea modelelor nutrigenomice pentru personalizarea tratamentelor dietetice in obezitate / The use of nutrigenomic models for personalization of dietetic treatments in obesity; Scientific Manager: Prof. Cristina Adriana Dehelean; 2016-2019
  10. PIII-C1-PCFI-2014/2015-03, Title: Noi abordări farmaceutice pentru modularea biodisponibilităţii unor flavonoide cu potenţial chemopreventiv pentru melanomul malign / New pharmaceutical options for some Flavonoids bioavailability modulation with chemopreventiv potential in malignant melanoma, Manager: Prof. Cristina Adriana Dehelean; 2014-2016

The scientific research within the discipline of Toxicology and the Drug Industry focuses on in vitro experimental studies (normal and tumor cell line cultures) and in vivo (experimental models of skin and breast cancer using laboratory animals). Another direction consists in obtaining crude and standardized plant extracts, isolation of biologically active compounds, studies for obtaining / characterizing (toxicological profile) some formulations (especially nanoformulations) with therapeutic impact. All this is part of the research profile of the second department of pharmaceutical sciences of which the discipline is part.

The research activity of the head of the discipline and its members is also materialized by the numerous patents of inventions, among which we mention:

  1. Butnariu M, Dehelean  CA,  Palicica RD,  Unguent  farmaceutic  si  procedeu  de  obtinere  pe  baza  de  flori  de galbenele  crescute  pe  soluri  imbogatite  cu  zinc  /  Pharmaceutical  ointment  based  on Marigold flowers  grown  in  zinc-enriched  soils  and  process  for  preparing  the  same, Patent no. RO122836 from 30.03.2010.
  2. Jumanca D, Galuscan A, Florita S, Podariu A, Florita Z, Dehelean C, Borcan F. Compoziție pentru pastă de dinți (Composition for toothpaste), Patent no 127805, OSIM / 28.II.2014
  3. Jumanca D, Gălușcan A, Borcan F, Florița S, Dehelean C, Florița Z. Procedeu și dispozitiv pentru producerea nanogelurilor și microgelurilor pe bază de silicați alcalino-pământoși (Procedure and device for producing nanogels and microgels based on alcalino-grand silicates), Patent no 128480, OSIM / 26.II.2016
  4. Pop G, Alexa E, Imbre I, Palicica R, Dehelean C, Danciu C, Andrica F. Unguent antibacterian pe bază de extract de măghiran (Origanum majorana L.) și scoarță de mesteacăn (Betula pendula Roth.), Registry office OMIS A/01015/17.12.2015, published in the Official Industrial Property Bulletin, Section Brevete de Inventie, No.6, 2016
  5. Faur V, Popovici RA, Faur A, Dehelean CA, Borcan F, Pînzaru IA, Șoica CM. Procedeu de obținere a unei creme pe bază de betulină, utilă în tratamente dermatologice / Process for obtaining a betulin based cream, useful in dermatological treatments, CBI A/00668 from 10.09.2018
  6. Borcan LC, Popescu FG, Borcan F, Păuncu EA, Tomescu MC, Dehelean CA. Produs absorbant pentru hidrogen sulfurat și procedeu de obținere a acestuia / Absorbent product for hydrogen sulphide and process for obtaining it. CBI A/00040 from 25.01.2019

Books and book chapters published in international publishing houses:

  1. Simona Cîntă Pînzaru, A. Fălămaș, C.A. Dehelean. Chapter 6 – Raman Spectroscopy: A Key Analytical Tool for New Drugs Research and Development (Edited by: Attaur Rahman) in: Studies in Natural Products Chemistry Volume 61, Pages 211-250. DOI: 10.1016/B978-0-444-64183-0.00006-3, ISBN: 978-0-444-64183-0, ISSN: 1572-5995, Elsevier 2018
  2. Codruta Soica, Iulia Pinzaru, Cristina Trandafirescu, Florina Andrica, Corina Danciu, Marius Mioc, Dorina Coricovac, Cassian Sitaru, Cristina Dehelean. Chapter 5 – Silver-, gold-, and iron-based metallic nanoparticles: Biomedical applications as theranostic agents for cancer, Pages 161-242, in: Design of Nanostructures for Theranostics Applications. Edited by: Alexandru Mihai Grumezescu ISBN: 978-0-12-813669-0, Elsevier 2018
  3. Elena Alina Moacă, Elena Dorina Coricovac, Codruta Marinela Soica, Iulia Andreea Pinzaru, Cornelia S Păcurariu, Cristina Adriana Chapter 12 – Preclinical aspects on magnetic iron oxides nanoparticles and their interventions as anticancer agents: enucleation, apoptosis and other mechanism, DOI: 10.5772/intechopen.74176, in: Iron ores and iron oxide materials, Edited by: Dr. Volodymyr Shatokha, ISBN 978-1-78923-320-9, InTech 2018
  4. Codruţa Şoica, Diana Antal, Florina Andrica, Roxana Băbuţa, Alina Moacă, Florina Ardelean, Roxana Ghiulai, Stefana Avram, Corina Danciu, Dorina Coricovac, Cristina Dehelean. Lupan-Skeleton Pentacyclic Triterpenes with Activity against Skin Cancer: Preclinical Trials Evolution, DOI: 10.5772/intechopen.68908, in: Unique Aspects of Anti-cancer Drug Development, Edited by: Jolanta Natalia Latosinska and Magdalena Latosinska, ISBN 978-953-51-3348-3, Print ISBN 978-953-51-3347-6, InTech 2017
  5. Stefana Avram, Roxana Ghiulai, Ioana Zinuca Pavel, Marius Mioc, Roxana Babuta,Mirela Voicu, Dorina Coricovac, Corina Danciu, Cristina Dehelean, Codruta Soica. Phytocompounds targeting cancer angiogenesis using the chorioallantoic membrane assay, in: Phytochemistry – Natural Products and Cancer, ISBN 978-953-51-3314-8, Print ISBN 978-953-51-3313-1, Intech 2017
  6. Corina Danciu, Suciu Oana, Diana Simona Antal, Florina Ardelean, Aimée Rodica Chiș, Codruța Șoica, Florina Andrica, Cristina Dehelean, Vlaicu Brigitha. New insights regarding the potential health benefits of isoflavones, pages: 257-286, in: Flavonoids, Edited by: José Justino, ISBN 978-953-51-5338-2, Intech 2017
  7. Danciu Corina, Soica Codruta, Antal Diana, Alexandra Popescu, Stefana Avram, Roxana Ghiulai, Ioana Zinuca Pavel, Minda Daliana, Cristina Dehelean. An update of natural compounds and their modern formulations for the management of malignant melanoma, pages: 211-253, in: Phytochemistry – Natural Products and Cancer, Edited by: Farid A. Badria, ISBN 978-953-51-3314-8, Print ISBN 978-953-51-3313-1, Intech 2017
  8. Dorina E. Coricovac, Cristina A. Dehelean. Chapter 1 – Pathological Aspects with Global Impact Induced by Toxicants at Cellular Level, pages 3-21, DOI: 10.5772/59945, in: Toxicology Studies – Cells, Drugs and Environment, Edited by: Ana Cristina Andreazza and Gustavo Scola, ISBN 978-953-51-2140-4, InTech 2015
  9. Codruţa Şoica, Cristina Trandafirescu, Florin Borcan, Corina Danciu, Georgeta Simu, Cristina Dehelean. Nanoformulations with cyclodextrins as carriers for skin targeting of active drugs, in: Biotechnology-Novel Drug Delivery, Volume 8, pages: 29-56, Series ISBN: 1-62699-015-8, Vol. ISBN No.: 1-62699-023-9, Studium press LLC, Houston, USA 2014
  10. Corina Danciu, Cristina Dehelean, Codruta Soica. Chapter 2 – Natural Compound Genistein: From Consecrated to New Utilizations and Formulations, in: Biotechnology – Drug Discovery, Volume 7, pages: 43-61, Series ISBN: 1-62699-022-0, Vol. ISBN: 1-62699-015-8, Studium Press, LLC, Houston, USA 2014
  11. Borza C, Muntean D, Dehelean C, Săvoiu G, Şerban C, Simu G, Andoni M, Butur M, Drăgan S. Chapter 2 – Oxidative stress and lipid peroxidation – a lipid metabolism dysfunction, in: Molecular aspects of lipid metabolism, Edited by: Rodrigo Valenzuela Baez, pages: 21-39, ISBN 978-953-51-0944-0, InTech 2013, intechopen.com

Collaborations

The Discipline of Toxicology and Drug Industry is in a continuous scientific collaboration with various disciplines within national and international universities. Among them, we mention:

  1. GERMANY
  • Clin Goethe Univ, Inst Gen Pharmacol & Toxicol, Pharmazentrum Frankfurt ZAFES, D-60590 Frankfurt, Germany
  • Goethe Univ Frankfurt, Inst Biochem Pathobiochem 1, D-60590 Frankfurt, Germany
  • Martin Luther Univ Halle Wittenberg, Dept Organ Chem, Kurt Mothes Str 2, D-06120 Halle, Saale, Germany
  • Univ Freiburg, Dept Dermatol, Hauptstr 7, D-79104 Freiburg, Germany
  • Signalhaus Freiburg, BIOSS Ctr Biol Signalling Studies, Schanzlestr 18, D-79104 Freiburg, Germany
  1. UNITED STATES OF AMERICA
  • Northeastern Univ, Sch Pharm, Dept Pharmaceut Sci, Boston, MA 02115 USA
  • Rutgers State Univ, New Jersey Inst Food Nutr & Hlth, 61 Dudley Rd, New Brunswick, NJ 08901 USA
  • Wright State Univ, Dept Chem, Dayton, OH 45435 USA
  1. GREECE
  • Univ Crete, Fac Med, Dept Forens Sci & Toxicol, Iraklion 71003, Crete, Greece
  • Univ Crete, Med Sch, Lab Clin Virol, Iraklion 71003, Crete, Greece
  1. HUNGARY
  • Univ Szeged, Inst Pharmaceut Technol & Regulatory, Szeged, Hungary
  • Univ Szeged, Dept Pharmacodynam & Biopharm, Szeged, Hungary
  • Gedeon Richter Plc, H-1103 Budapest, Hungary
  • Dr Derm Clin Antiaging Dermatol Aesthet Laser & P, H-1026 Budapest, Hungary
  • Univ Szeged, Dept Dermatol & Allergol, H-6720 Szeged, Hungary
  • Univ Szeged, Dept Oral Biol & Expt Dent Res, H-6720 Szeged, Hungary
  1. FRANCE
  • Aix Marseille Univ, Fac Pharm, 27 Jean Moulin Blvd, F-13385 Marseille 5, France
  • Université Université de Lorraine, Bvd des Aiguillettes 54506 Vandoeuvre les Nancy, France
  1. ENGLAND
  • Aston Univ, Pharmaceut Dept, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England
  • Middlesex Univ London, Dept Nat Sci, London, England
  1. AUSTRIA
  • Univ Vienna, Dept Struct & Computat Biol, Max F Prutz Labs, Vienna, Austria
  • Univ Vienna, Fac Phys, Quantum Opt Quantum Nanophys & Quantum Informat, Vienna, Austria
  1. ITALY
  • University of Calabria, Department of Pharmacy, Health and Nutritional Science, via Pietro Bucci, 87036 Arcavacata di Rende (CS), Italy.