Name of the research center: Research center for pharmaco-toxicological evaluations/ acronym FARMATOX
Director of the research center: Professor CRISTINA ADRIANA DEHELEAN
Date of establishment: 05.03.2021
The coordinator of the Research Center for Pharmaco-toxicological Evaluation along with UMFT team members are currently involved in eight research projects addressing topics such as: (1) Delivery to the dermocosmetic market of a modern topical formulation with betulinic acid encapsulated in proniosomes (PN-III-P1-1.1-TE-2019-2134); (2) Innovative hydrogels containing polymeric micelles as drug delivery systems for oregano essential oil: an advanced pharmaceutical approach for the management of skin tags (PN-III-P1-1.1-TE-2019-0130); (3) New perspectives on skin cancer chemoprevention: evaluation of maslinic acid and of a maslinic acid derivative incorporated into nanoemulsions (PN-III-P1-1.1-PD-2019-1231); (4) Synthesis and assessment of novel triazole-triterpene-gold nanoparticle bioconjugates, used as active agents in malignant melanoma (PN-III-P1-1.1-PD-2019-1078); (5) Lupeol as bioactive natural compound in the local treatment of wounds and inflammation from mild to severe pathologies: experimental evaluations and market pre-proposal (1EXP / 1233 / 30.01.2020); (6) Populi gemmae – a double gain for the pharmaceutical field: therapeutic potential and bio-source for green synthesis of silver nanoparticles (3POSTDOC / 1238 / 30.01.2020); (7) Cooperation on innovation and exchange of good practice in the diet of hypoglycaemia for people with diabetes (2019-1-RO01-KA203-063499); (8) Innovative nanobiostructures based on bioconjugated ferromagnetic nanoparticles with cyclodextrins to increase efficacy and reduce toxicity in cancer therapy by SP-magnetic hyperthermia (PN-III-P2.1-PED-2019-3067). A large number of ISI publications supports our activity.
Our offer and research activity consist in performing analyzes, determinations, tests, evaluations, on three main directions:
- Synthesis and physico-chemical characterization – obtaining new compounds, standardized extracts and modern pharmaceutical formulations (based on metallic nanoparticles, cyclodextrins, nanoemulsions, hydrogels, liposomes, niosomes, etc.) and their complete characterization to correspond to the pharmaceutical and medical fields. Also, the possibility of characterizing these types of compounds/products for the profile industry.
- In vitro testing – pharmaco-toxicological screening based on in vitro methods ECVAM (European Center for the Validation of Alternative Methods) validated and included in GIVIMP (Guidance Document on Good in Vitro Method Practices). Are evaluated: cell viability, cytotoxicity, apoptosis/necrosis, cell morphology (immunofluorescent staining), cell migration / invasion, oxidative stress (by various tests such as MTT, LDH, DAPI, Hoechst 33342, scratch assay, etc.) and acute toxicity, phototoxicity/photoirritation (reconstructed human tissues – 3D – EpiDerm ™), according to OECD TG 439; OECD 405, OECD 432 and others.
- In vivo evaluation – is performed depending on the research topic: (i) on the embryonated egg to complete the pharmaco-toxicological profile; (ii) on different animal models to clarify the mechanisms involved and (iii) on volunteers by non-invasive methods being monitored physiological parameters of the skin (e.g., hydration, transepidermal water loss, sebum content, melanin, erythema, pH, color, elasticity, temperature, microcirculation, etc.).
Some of the mentioned tests can be used to evaluate products from the industry like food supplements, cosmetics, etc.
We are open to any collaborations that successfully complete the presented activities.
Titular members:
No. | Name and surname of the titular member (didactic/ research personnel) | Didactic/ research degree |
1. | Dehelean Cristina Adriana | Professor, PhD |
2. | Flondor Daniela | Associate Professor, MD, PhD |
3. | Pînzaru Iulia Andreea | Associate Professor, PhD |
4. | Coricovac Elena Dorina | Associate Professor, PhD |
5. | Moacă Elena Alina | Lecturer, PhD |
6. | Iftode Oana Andrada | Lecturer, MD, PhD. |
7. | Drăghici George Andrei | Assistant Professor, PhD |
8. | Macaşoi Ioana Gabriela | Assistant Professor |
No. | Name and surname of the titular member (didactic/ research personnel) | Didactic/ research degree |
1. | Şoica Codruţa | Professor, PhD |
2. | Trandafirescu Cristina | Associate Professor, PhD |
3. | Ghiulai Roxana | Associate Professor, PhD |
4. | Mioc Marius | Associate Professor, PhD |
5. | Racoviceanu Roxana | Lecturer, PhD |
No. | Name and surname of the titular member (didactic/ research personnel) | Didactic/ research degree |
1. | Danciu Corina | Professor, PhD |
2. | Avram Ştefana | Associate Professor, PhD |
3. | Pavel Ioana Zinuca | Lecturer, PhD |
4. | Minda Daliana | Assistant Professor, PhD |
N0: | Name and surname of the titular member (didactic/ research personnel) | Didactic/ research degree |
1. | Buda Valentina Oana | Associate Professor, PhD |
2. | Voicu Mirela | Associate Professor, PhD |
3. | Suciu Maria | Lecturer, PhD |
4. | Suciu Liana | Lecturer, PhD |
5. | Mabda (Proks) Maria-Cristina | Assistant Professor, PhD |
Associated members:
No. | Name and surname | Student, masters student, PhD student, postdoctoral student, auxilliary and non-teaching staff |
1. | Marcovici Iasmina | Assistant Lecturer, MD, PhD |
2. | Dolghi Alina | Assistant Lecturer, MD, PhD |
3. | Scurtu Alexandra – Denisa | Assistant Lecturer, MD, PhD |
4. | Szabo Eliza | PhD student |
5. | Moza Iren | PhD student |
6. | Petean Crina | PhD student |
7. | Nistor Gabriela | PhD student |
8. | Roșca Oana | PhD student |
9. | Milan Andreea | PhD student |
10. | Ulici Alexandra | PhD student |
11. | Ghitu Alexandra | PhD student |
12. | Kis Brigitha | PhD student |
13. | Fecker Ramona | PhD student |
14. | Lombrea Adelina | PhD student |
15. | Bora Larisa | PhD student |
16. | Stoicescu Emil | PhD student |
Internal collaborators:
No. | Name and surname (didactic/ research personnel) | VBUMP Affiliation (Discipline and Department) |
1. | Professor, PhD. Vlaia Lavinia Lia | Pharmaceutical Technology Discipline, Department II, Faculty of Pharmacy |
2. | Lecturer, PhD Georgeta Hermina | Pharmaceutical Technology Discipline, Department II, Faculty of Pharmacy |
3. | Lecturer, PhD. Olariu Ioana Viorica | Pharmaceutical Technology Discipline, Department II, Faculty of Pharmacy |
4. | Assistant Professor, PhD. Muț Ana Maria | Pharmaceutical Technology Discipline, Department II, Faculty of Pharmacy |
5. | Associate Professor, PhD Vlaia Vicențiu | Discipline of Organic Chemistry, Department I, Faculty of Pharmacy |
6. | Professor, PhD. Antal Diana | Pharmaceutical Botanical Discipline, Department I, Faculty of Pharmacy |
7. | Assistant Professor, PhD. Ardelean Florina | Pharmaceutical Botanical Discipline, Department I, Faculty of Pharmacy |
8. | Associate Professor, MD, PhD. Muntean Delia | Discipline Microbiology-Virology, Department XIV: Microbiology, Faculty of Medicine |
9. | Professor, MD, PhD Muntean Mirela-Danina | Discipline Pathophysiology, Department III: Functional Sciences, Faculty of Medicine |
10. | Associate Professor, MD, PhD. Aburel (Duicu) Oana Maria | Discipline Pathophysiology, Department III: Functional Sciences, Faculty of Medicine |
11. | Lecturer, PhD. Dănilă Maria-Daniela | Discipline Pathophysiology, Department III: Functional Sciences, Faculty of Medicine |
12. | Associate Professor, MD, PhD. Sturza Adrian | Discipline Pathophysiology, Department III: Functional Sciences, Faculty of Medicine |
13. | Professor, MD, PhD. Marian Cătălin | Department IV Biochemistry and Pharmacology, Discipline of Biochemistry, “Victor Babeș” University of Medicine and Pharmacy in Timișoara, Timișoara, Romania |
14. | Professor, MD, PhD. Camelia Szuhanek | Discipline of Orthodontics, “Victor Babeș” University of Medicine and Pharmacy in Timișoara, Timișoara, Romania |
15. | Professor, MD, PhD. Daliborca Vlad | Department IV Biochemistry and Pharmacology, Discipline of Pharmacology, “Victor Babeș” University of Medicine and Pharmacy from Timișoara, Timișoara, Romania |
16. | Associate Professor, MD, PhD. Baderca Flavia | Department II Microscopic Morphology, Histology Discipline, “Victor Babeș” University of Medicine and Pharmacy from Timișoara, Timișoara, Romania |
17. | Associate Professor, MD, PhD. Roxana Oancea | Discipline of Preventive Dentistry, Community and Oral Health, “Victor Babeș” University of Medicine and Pharmacy in Timișoara, Timișoara, Romania |
18. | Associate Professor, MD, PhD. Roxana Popescu | Discipline of Cellular and Molecular Biology, “Victor Babeș” University of Medicine and Pharmacy in Timișoara, Timișoara, Romania |
19. | Lecturer, PhD. Mioc Alexandra | Departamentul I, Disciplina de Anatomy, Physiology, Pathophysiology, Faculty of Pharmacy, Victor Babeș University of Medicine and Pharmacy in Timișoara, Timișoara, Romania |
20. | Assistant Professor, PhD. Watz (Farcaș) | Department I, Discipline of Pharmaceutical Physics, Faculty of Pharmacy, Victor Babeș University of Medicine and Pharmacy from Timișoara, Timișoara, Romania |
21. | Associate Professor, MD, PhD Iacob Daniela | Childcare and Neonatology, Department XII Obstetrics-Gynecology, Victor Babeș University of Medicine and Pharmacy in Timișoara, Timișoara, Romania |
External collaborators:
No. | Name and surname (didactic/ research personnel) | Affiliation (Department, institution/university, city, country) |
1. | Professor, MD, PhD. Spandidos Demetrios | Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece. |
2. | Professor, MD, PhD. Heinfried H. Radeke | Pharmazentrum Frankfurt/ZAFES, Institute of General Pharmacology and Toxicology/ Clinic of the Goethe University, D-60590 Frankfurt/Main, Germany |
3. | Professor, MD, PhD. Pavel Ioana | Dept Chem, Wright State Univ, Dayton, OH 45435 USA |
4. | Professor, Andreea Pasc | Univ Lorraine, L2CM UMR CNRS 7053, F-54506 Vandoeuvre Les Nancy, France |
5. | Professor Giancarlo Statti | Department of Pharmacy, Health and Nutritional Science, University of Calabria, via Pietro Bucci, 87036 Arcavacata di Rende (CS), Italy |
6. | Professor Filomena Conforti | Dipartimento di Farmacia e Scienza della Salute e della Nutrizione, University of Calabria, via Pietro Bucci, 87036 Arcavacata di Rende (CS), Italy |
7. | Professor, MD, PhD. Ersilia Alexa | Department of Food Control, Banat’s University of Agricultural Sciences and Veterinary Medicine “King Michael I of Romania” from Timi¸soara, Calea Aradului No. 119, 300641 Timisoara, Romania |
8. | Professor, MD, PhD. Laurian Vlase | Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Pharmaceut Technol & Biopharmaceut, 12 Ion Creanga St, Cluj Napoca 400010, Romania |
9. | Lecturer, MD, PhD Diaconeasa Zoriţa Maria | Discipline: Biochemistry, Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, România, Cluj-Napoca |