Name of the research center: ANGIOGENESIS RESEARCH CENTER, TIMISOARA/ acronym ANGIOTM

Director of the research center: Professor Marius Raica MD, PhD.

Date of establishment/ acknowledgement: 05.03.2021

Research areas/ research opportunities:

Angiogenesis Research Center Timisoara was established in 2007, out of the desire to focus resources on the topic of maximum interest for angiogenesis. The center was organized by Professor Marius Raica and Professor Anca Maria Cîmpean, including morphological methods, molecular and experimental biology, which allow the investigation of a wide range of events related especially to tumor angiogenesis.

Angiogenesis Research Center includes the following compartments:

  1. Primary tissue processing laboratory;
  2. Conventionalmicroscopy laboratory, with fluorescence in ApoTome system and virtual microscopy;
  3. Laser Capture Microdissection Microscopy Lab.;
  4. Micro-Array Tissue Laboratory;
  5. Automated immunohistochemistry laboratory;
  6. Molecular pathology laboratory: DNA extraction and analysis; RNA, in situ hybridization with chromogen and fluorescence, classical RT PCR techniques and in TaqMan Array system;
  7. Laboratory of experimental medicine on chorioallantoic membrane model and rabbit cornea model.

The main research directions of the Angiogenesis Research Center are:

  1. Study of angiogenic mechanisms associated with solid malignancies (breast, clear cell renal cell carcinoma, squamous cell carcinoma of the head and neck, malignant melanoma);
  2. Investigation of the structure and molecular profile of neoformation vessels;
  3. Identification of the sequential effect of growth factors on the stages of angiogenesis;
  4. Therapeutic targets for antiangiogenic and antivascular therapy;
  5. Development of new experimental models;
  6. Innovative methods for assessing the proliferative nature of endothelial cells;
  7. Characterization of progenitor mesenchymal and endothelial stemcells in culture;
  8. Involvement of tumor-associated blood and lymph vessels in the metastatic process;
  9. Development of monoclonal antibodies that inhibit the proliferation of blood and lymph endothelial cells in neoformation vessels;
  10. Identification and molecular characterization of “type cells”.
Members list:

Titular members:

Nr.

Name and surname of the titular member (didactic/ research personnel)

Didactic/ research degree

1.

RAICA MARIUS

Professor MD, PhD

2.

CÎMPEAN ANCA-MARIA

Professor MD, PhD

3.

CEAUȘU AMALIA-RALUCA

Associate Professor MD, PhD

4.

GAJE NELA-PUȘA

Associate Professor MD, PhD

5.

COMȘA ȘERBAN

Senior Lecturer MD, PhD

 

Associated members:

Nr.

Name and surname

Student, masters student, PhD student, postdoctoral student, auxilliary and non-teaching staff

1.

SÂRB SIMONA

Senior Lecturer MD, PhD

2.

BARB ALINA-CRISTINA (TOMA)

Assistant Lecturer, PhD

3.

COSMA ANDREI-ALEXANDRU

Assistant Lecturer, PhD

4.

BERZAVA PATRICIA-LORENA

Lab assistant

5.

ONICĂ EMANUEL-CIPRIAN

Lab assistant

6.

TOGERONI NADIA GEORGETA MARSILIA

Secretary

7.

CUMPANAȘ ANDREI DRAGOȘ

Student

 

External collaborators:

Nr.

Name and surname

(didactic/ research personnel)

Affiliation

 (Department,

institution/university, city, country)

1.

DOMENICO RIBATTI MD. PhD, Professor

Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Italy

2.

VALENTIN DJONOV MD, PhD, Professor

University of Bern Section of Topographic and Clinical Anatomy, Institute of Anatomy, Bern, Switzerland

3.

ARJAN W. GRIFFIOEN MD, PhD, Professor

Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center Amsterdam, The Netherlands

4.

DUSAN LALOŠEVIĆ MD, PhD,Professor

Department of Histology and Embryology, Faculty of Medicine, University of Novi Sad, Serbia.

5.

BELA MOLNAR MD, PhD,Professor

3D HISTECH, Budapest, Hungary

6.

MELNIC EUGEN MD, PhD, Associate Professor

·       State University of Medicine and Pharmaceutics „Nicolae Testemiţanu”

Department of Morphology, Chisinau, Moldova

7.

ADOLF ELLINGER MD, PhD, Professor

Medical University of Vienna

·       Department of Cell Biology and Ultrastructure Research

·       Vienna, Austria