Name of the research center: Multidisciplinary Research Center for Malignant Hemopathies

Director of the research center: Associate Professor Ioana Ionita MD, PhD

Date of establishment/ acknowledgement: 05.03.2021

Research areas/ research opportunities:

In the last decades we have experienced an increase in hematological malignancies, due to this, the hematological area of research has gained more and more attention. Although newer classifications of hematologic diseases include a variety of genetic abnormalities,  Flow cytometric immunophenotyping is still an indispensable tool for diagnosis, classification, staging, and monitoring of hematologic neoplasms.

Phenotypically abnormal populations have been documented in many hematologic neoplasms, including lymphoma, chronic lymphoid leukemias, plasma cell neoplasms, acute leukemia, paroxysmal nocturnal hemoglobinuria, mast cell disease, myelodysplastic syndromes, and myeloproliferative disorders. In addition, flow cytometry is a useful tool for staging a previously diagnosed hematolymphoid neoplasm, monitoring response to treatment including detection of minimal residual disease (MRD), documenting relapse or progression, and diagnosing an intercurrent hematologic malignancy.  Moreover, the provision of immunophenotypic information may have additional value, including the identification of targets for a potential targeted therapy.

Nowadays, hematology endorses a multiparametric approach to diagnosis and outlines the morphologic, immunophenotypic, and genotypic features characteristic of each disease entity. With this in mind, our center plans to corroborate preclinical and clinical investigations and gain more knowledge of the phenotypes of diverse normal cell populations and recognize deviations from the normal to be able to discuss the potential clinical significance of the flow cytometric findings.

We are open to collaboration in the fields of genetics, molecular biology, anatomopathology, immunology, pharmacology, cardiotoxicity.

Members list:

Titular members:

Nr.

Name and surname of the titular member (didactic/ research personnel)

Didactic/ research degree

1.

IONITA IOANA

Associate Professor MD, PhD

2.

IORDACHE MARIA

Assistant Lecturer MD, PhD

3.

CALAMAR POPOVICI DESPINA

Assistant Lecturer MD, PhD

4.

OROS DACIAN

Assistant Lecturer MD, PhD

5.

TODORESCU VIOLETA

Assistant Lecturer MD, PhD

6.

POTRE ONCU OVIDIU SEBASTIAN

Assistant Lecturer MD, PhD

7.

POTRE ONCU CRISTINA

Assistant Lecturer MD, PhD

8.

BORSI EMA CRISTINA

Assistant Lecturer MD, PhD

9.

LIGHEZAN DIANA LUISA

Assistant Lecturer MD, PhD

 

Associated members:

Nr.

Name and surname

Student, masters student, PhD student, postdoctoral student, auxilliary and non-teaching staff

1.

GURBAN CATALINA

PhD student

2.

BALANESCU ANDRADA

PhD student